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Silverman JL, Oliver CF, Karras MN, Gastrell PT, Crawley JN

The microneedling creates micro-channels that deliver copper peptides directly to the dermal papilla the exact target cells identified in Pyo et al.'s 2007 work

Carcinogenesis 20 , 553559 (1999)

These in vitro results demonstrated that H2O2 induces Leydig cell senescence, accompanied by FOXO4 nuclear translocation and activation of senescence pathways