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Effect of NNMT inhibitor on adipocyte differentiation quantitated with oil red O staining 3T3-L1 cells were cultured in 60 mm diameter dishes (8.410 4 cells/dish) and treated with NNMT inhibitor dissolved in culture media with/without adipogenic factors (1 mM IBMX, 1 M dexamethasone, 10 g/ml of insulin) during each of the scheduled media changes during the differentiation process (described above)
M.et al (2019)
discovered that the mA demethylase ALKBH5 delays the progression of diabetic retinopathy by inhibiting ferroptosis via the mAYTHDF1ACSL4 axis, suggesting its potential as a therapeutic target [169]
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