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Molecular Behaviour and Research Mechanisms Interaction with intracellular signalling and signal transduction pathways Influence on gene transcription and molecular activation cascades Modulation of growth factor sensitivity in controlled in-vitro systems Relationship with mitochondrial ATP dynamics and metabolic behaviour Support of enzymatic response and pathway-driven experimental models Common Research Applications Across Europe Regenerative Cell Biology Models: Studying controlled cellular behaviour and structural response mechanisms

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doi: 10.1046/j.1365-313x.2002.01427.x

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Supporting evidence: Flattened diurnal slopes, attenuated cortisol awakening response, eveningpredominant DHEAS, and paradoxical elevations of salivary sex steroids under low cortisol/DHEAS conditions illustrate how chronic inflammation reprograms endocrine networks