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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Calvo-Rodriguez M, Hou SS, Snyder AC, Kharitonova EK, Russ AN, Das S, et al

10.3390/ijms22126627 291

Binding data are reported as means s.d

Widespread use of DOACs began in 2010 due to multiple factors, including 421 : Standardized dosing Decreased frequency of follow-ups Less adverse effects Fewer medication and food interactions Quicker onset of action Because of these factors, DOACs are generally preferred over warfarin by both patients and physicians

Recognizing these roles highlights aspartates central place in cellular metabolism and nucleotide production.