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2) Peptide Therapy - tenocytes (tendon cells) can be pharmacologically stimulated to lay down new layers of collagen

8 This was the first trial in patients with a first acute demyelinating event (now, clinically isolated syndrome) to show efficacy in delaying time-to-clinically definite MS and was recognized as a significant medical advance as it introduced the concept of early treatment and led to revisions in diagnostic criteria for MS
2012 Sep;41(5):547-52

Indeed, the bell curve predicts that such an event is a practical impossibility

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