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In locally advanced (stage III) NSCLC, most fit patients receive concurrent chemotherapy with a platinum-doublet and RT (CCRT), followed by one year of durvalumab (anti-PD-L1) therapy [3]

Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 cooperates with glycogen synthase kinase-3 to regulate osteogenesis of bone-marrow mesenchymal stem cells in type 2 diabetes

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For example, enhancing neuronal glucose uptake and utilization or modulating specific metabolic pathways could provide protective effects against metabolic stress and neurodegeneration (Riera and Dillin, 2015)

Epigenetic events are essential to regulate the condensation state of chromatin and hence to regulate the function of genome by means of histone modifications, chromatin remodeling, DNA methylation and no-coding RNA [9] Fig