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PLoS One, 6 (9), e24406
both are downstream consequences of the same systemic glutathione depletion and unchecked oxidative stress

Ascorbic acid addition to folate with fructose before heating prevented 5-methyl-THF degradation 557
the bulky 2-naphthyl side chain is essential for potency and selectivity D-Phenylalanine (position 4):Contributes to metabolic stability and receptor-binding specificity

doi: 10.1016/j.redox.2018.02.018
