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Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1alpha activation

While the C-terminal unit (C0362) is secreted and functions as a cysteine protease that disarms the complement system via degrading key complement factors such as C3 and C4, the N-terminal functional unit (N0362) with two Big domains binds to FPR1 and CXCR1/2 receptors with high affinity and blocks neutrophil chemotaxis and activation most likely through competition inhibition, thereby annihilating both the complement system and neutrophils and rendering bacteria protection from these two innate defense mechanisms

Iron levels influence macrophage polarization: low levels inhibit anti-inflammatory responses, while high levels promote them (Ma et al., 2022)

Phytomedicine 58, 152769

According to the myosin heavy chain (MyHC) subtype, muscle fibers can be divided into oxidative slow muscle fibers (type I) and glycolytic fast muscle fibers (types IIa, IIx, and IIb)