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In addition, application of the P-15-containing graft substitutes was found to accelerate the process of early bone formation response but not the long-term effect [129, 131, 135]

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Antioxidant responses, particularly those initiated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2) signaling, have been demonstrated to play a pivotal role in restoring redox balance and constraining the progression of fibrosis or HCC (Kundu and Surh 2010)

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