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Physiological roles of aquaporin-4 in brain

Two classes of drugs can alter selenocysteine-dependent translation to suppress GPx1 expression
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This excitatory-inhibitory dysregulation is further implicated in the frequent co-occurrence of tinnitus with anxiety and sleep disorders, suggesting shared neurobiological substrates involving maladaptive auditory-limbic network connectivity and neurotransmitter imbalances (Jiang et al., 2025)

The level of metalloproteins in the plasma is increased, and the level of RAS proteins is decreased, which results in the activator protein-1 (AP-1), by PI3K/Akt, JNK, p38 MAPK, and ERK signaling pathways [73]
