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These changes in turn could lead to cell clustering, and a degenerative disc cell phenotype (Fig
In response to stress, low expression of PGC-1 results in a reduction in ATP synthesis and an increase in ROS production, which in turn leads to dopamine neuron loss or damage
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In this condition, the brain isnt supplied with enough of its fuelglucoseto produce all of the ATP it requires to function
When treating these patients, it is essential to find a balance between the relaxing effects of BoNTA and preservation of residual motor function
