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Additionally, IGF-1 administration has been associated with increased tubular phosphate reabsorption.57,58 In the same way, other clinical studies have reported beneficial effects of recombinant IGF-1 on GFR in ESRD patients scheduled to begin renal replacement therapy or patients undergoing peritoneal dialysis.59,60 In vitro studies have supported the renal protective effects of IGF-1

doi: 10.3389/fnmol.2024.1504802 166 MeyerJNLeuthnerTCLuzAL

[DOI] [PubMed] [Google Scholar] 49.Wan XH, Lee EH, Koh HJ, et al

J Lipid Res 52(5):873884 Fruchart JC (2013) Selective peroxisome proliferator-activated receptor modulators (SPPARM): the next generation of peroxisome proliferator-activated receptor -agonists

As a consequence, the brains chemistry differs from that of normal mice with region-specific changes in the expression of 5-HT and brain derived neurotrophic factor (BDNF) (Wrase et al., 2006