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Of the six clinical trials included in the systematic review considered to have a low risk of selection bias due to adequate allocation concealment, only the RESTORE trial reported a notable benefit of treatment in preventing exacerbations [102]

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Certain histological characteristics of IC, such as the thinning of the bladder epithelium, erosion, and heightened mast cell infiltration, suggest that the condition may result from a deficiency in the regenerative capacity of bladder epithelial cells, along with immune system dysfunction (Slobodov et al., 2004)

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Identification of secreted proteins from Fr-DEGs in all cells Interactions between cells is a key feature in the cellular activities of multicellular life 20