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Morphologically, when ferroptosis occurs, mitochondria exhibit atrophy, increased membrane density, reduced or absent cristae, and ruptured outer membrane, whereas the cell membrane remains intact, and the nucleus appears normal [13]

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Another study using primary cortical neurons cultured from Pink1 -deficient mice revealed that FKBP5 can reduce Akt phosphorylation and promote MPP + -mediated neuronal death in the absence of Pink1 [91]