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Rev Hosp Clin Fac Med Sao Paulo
[11] [3] This is the rate limiting step
Concurrently, NAD + depletion, exacerbated by poly(ADP-ribose) polymerase-1 (PARP-1) hyperactivation, cripples sirtuin activity, impairing mitochondrial biogenesis via peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) dysregulation and reducing antioxidant defense through Forkhead box O (FOXO) signaling
doi:10.1093/jn/132.6.1634S
[DOI] [PubMed] [Google Scholar] 218.Wiens D, DeSoto MC
