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Research Applications This selective activity makes AOD9604 an attractive candidate for obesity treatment and body composition optimization research, as it theoretically provides the metabolic benefits of growth hormone for fat reduction without the growth-promoting effects that could stimulate cancer cell proliferation, cause acromegaly-like symptoms, or induce insulin resistance

They are fundamentally different in mechanism, evidence, regulatory status, and clinical effect

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Notably, stimulation of the HPA axis by AgRP neurons is independent of their induction of hunger, showing that these canonical hunger neurons drive many distinctly different adaptations to the fasted state