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Description
The GPX1 gene is located on chromosome 3p21.31 and is composed of 2 exons that generate five alternatively spliced mRNAs via the use of alternative splice donor or splice acceptor sequences
26 These subjects are characterized by a decreased capacity to activate the pentose phosphate pathway (PPP) and thus to generate the nicotinamide adenine dinucleotide phosphate (NADPH) necessary to reduce oxidized glutathione (GSH) and NADPH-dependent antioxidant enzymes
HAP1 mediates the axonal transport of BDNF, with prior studies demonstrating that HAP1 / mice display aberrant BDNF trafficking as indicated by alterations in BDNF distribution throughout the neuron and decreased activity-dependent release of proBDNF [18, 19]
Even if imaging looks normal, brain chemistry and function can remain disrupted for days to weeks
Dordanihaghighi S
