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doi: 10.1007/s12402-012-0086-2

10.1172/jci.insight.124079 54 HuT.WuQ.YaoQ.JiangK.YuJ.TangQ

Menter A, Gottlieb A, Feldman SR, et al

Specific strains such as Bifidobacterium lactis and Bifidobacterium bifidum have been documented to improve tear secretion and BUT ( Saccharomyces boulardii MUCL 53837 and Enterococcus faecium LMG S-28935 have been effective in alleviating subjective symptoms of DED ( Bifidobacterium and Lactobacillus plantarum not only increased tear secretion but also repaired CECs and reduced inflammatory markers like TNF- and IL-1 (Yun et al., 2021)

Rating the quality of evidencestudy limitations (risk of bias)