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Although LDH is primarily used clinically as a prognostic biomarker reflecting tumor burden, growing evidence suggests that it also plays functional roles in tumorigenesis and progression (41)

Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer

Since both glucose and fatty acids could contribute to histone acetylation, we reasoned that this could occur either by two distinct substrate-specific mechanisms or a mechanism in which these substrates can feed into a common precursor acetyl-CoA pool (e.g., in mitochondria) that is then transported to the nuclear-cytosolic compartment (Supplemental Figure 5E)

GSH, the most abundant thiol in cells, is capable of reacting directly with ROS and prevent damage to macromolecules

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