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The MG level of D-LDHKO cells was recorded to be the highest followed by GLYIKO cells which accumulated a little less MG than D-LDHKO cells (Fig

These figures cause a significant increase in the cost in health systems

This theory has been augmented by several studies that demonstrated increased markers of oxidative stress (by-products of non-enzymatic lipid peroxidation) in children suffering from konzo as well as documentation of deficiencies in micronutrients which are required to maintain effective antioxidant response in konzo-prone populations 18,19

In AD, DNA hypermethylation has been reported in the promoters of genes involved in synaptic plasticity, memory formation, and neuroinflammation, potentially contributing to the cognitive decline and neurodegeneration (156, 157)