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We have previously shown that retinal flavin levels decline with age in several retinal degenerative and diabetic models [20], and some diabetic patients suffer from systemic flavin deficiency [1,20]

An altered ratio of hypohalous acid formation by MPO can markedly affect both the innate immune defense and the extent and nature of damage to host tissues

In particular, brain organoids are revolutionizing the study of mitochondrial-based neurological diseases since they are organ-specific and model-generated from a patients cell, thereby overcoming some of the limitations of traditional animal and cell models

[DOI] [PubMed] [Google Scholar] 202.Alobeidat S, Athamneh T

After treatment, the medium was removed, and 20 L/well of fresh medium containing luminogenic CYP substrate was added, followed by a 1-hour incubation at 37 C