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Elevated CD47 expression on healthy RBCs promotes immunological tolerance and extends circulation duration, whereas reduced CD47 density on elderly or injured RBCs acts as a clearance signal (15, 21, 22)

In addition, exogenous supply of BDNF to neuronal cultures promotes survival by preventing apoptosis [112]

Researchers typically reconstitute it in sterile aqueous buffer for in vitro and preclinical in vivo model use

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