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The mechanism involves melanin

doi:10.1002/14651858.CD010676.pub2 Slee A, Nazareth I, Bondaronek P, Liu Y, Cheng Z, Freemantle N

B., and Jacobs L., FluidAttenuated Inversion Recovery Magnetic Resonance Imaging Detects Cortical and Juxtacortical Multiple Sclerosis Lesions, Archives of Neurology 58, no

Patients with long-standing alcohol use, restrictive diets, malabsorption syndromes, or prolonged use of medications that deplete or interfere with B vitamins may particularly benefit when a deficiency is confirmed