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Together with IL-12 and IL-18 or transforming tumor necrosis growth factor (TGF)-, IL-6, and IL-23, TNF- induces the differentiation of nave CD4+ T cells into pro-inflammatory T helper cells of type 1 (T H 1) and type 17 (T H 17), respectively [6,12,13]

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doi: 10.3389/fimmu.2020.01712

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This mechanistic complementarity makes GHK-Cu scientifically interesting as a potential combination research tool studying whether GHK-Cus direct follicle trophic effects add to or synergise with DHT-axis treatments is a logical research question that remains incompletely explored