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Circulating levels of IGF-1 appear to play a major role in bone remodeling and have a direct impact on linear bone growth, as shown by various skeletal parameters evaluated in this study
Furthermore, CK-18 levels have also been shown to be related to systemic inflammation markers
and (7) developing an international consensus framework to guide experimental design, endpoint selection, and data transparency
Hardeland R, Tan DX, Reiter RJ
doi: 10.1001/jamapediatrics.2022.4401
