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Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)

Am J Clin Nutr 63(3):348353 Johnson PE, Hunt CD, Milne DB, Mullen LK (1993) Homeostatic control of zinc metabolism in men: zinc excretion and balance in men fed diets low in zinc