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Inositol seems to modestly improve lipid parameters, blood pressure, and insulin resistance in patients with metabolic syndrome

TMAO promotes macrophage infiltration and activation within adipose tissue, driving a shift in macrophage phenotype toward the pro-inflammatory M1 state, contributing to adipose tissue dysfunction, a key hallmark of obesity-related metabolic dysfunction [30, 75]

Such conditions include obesity and type 2 diabetes mellitus.] Figure 18.17 Metabolism of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL)

In the microenvironments of breast cancer and pancreatic cancer, the expression of the key glycolytic enzymes PKM2 and LDHA in CAFs is increased [324, 325]

Further mechanistic investigations are warranted to clarify the exact mechanisms mediating the synergistic effect of L-carnitine and synbiotic combined therapy on weight and metabolic parameters