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In in vitro hypoxic conditions, -KG can induce the degradation of HIF-1 in Lewis lung carcinoma, which can inhibit angiogenesis in mouse tumor models and exert an antitumor effect [32]

Furthermore, Sucrosomial B12 was well-tolerated, with no reported side effects, serious adverse events, or treatment-emergent effects, no negative effect on the vital signs, confirming its excellent safety and tolerability

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Acute UV radiation has been linked to skin burns, oedema, abnormal pigmentation, and photokeratitis, and long-term exposure increases the risk of photoaging and malignant tumours [85,86,284,286,287]