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For these characteristics, ATRA was considered as a novel therapeutic strategy for AD treatment, as an additional alternative to the vitamin A supplement

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Their GATA1 mutations are frameshifts in exon 2 that result in the failure to make GATA1 protein, continued formation of GATA1-S, and thus a greatly reduced ability to regulate GATA1-targeted genes

Also, GB modulates the activity and expression of specific ion transporters and channels, such as H + -ATPases and metal transporter families (ZIP, NRAMP), enhancing selective uptake and sequestration of essential ions while limiting toxic metal accumulation (Hasanuzzaman et al., 2020)

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