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In addition to the acquirement of drug-resistant mutation, the development of cancer stem cells also causes CML persistence and relapse from TKI therapy 12,13,14

Therefore, there is an urgent need to identify the brain circuits that are primarily affected by sleep deprivation (e.g., over-activated wake circuits), which could be targeted to alter the efficacy of MORs in providing pain relief without producing opioid tolerance

S., Benedetto A., Biophys

With healthy lifestyle changes and effective treatment, many people may be able to prevent advanced-stage CKD

Associations of processed meat, unprocessed red meat, poultry, or fish intake with incident cardiovascular disease and all-cause mortality