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Tobacco-associated lesions of the oral cavity: Part I
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DHA was discovered as a skin-browning agent in the 1920s, when healthcare providers noticed localized skin darkening in children being treated orally with DHA for glycogen storage disease
The key difference between the MALDI and ESI ionization sources lies in the former producing low-charge ions (mono and doubly-charged), which simplifies molecular mass determination for most biomolecules and makes data interpretation easier compared to ESI-MS
