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In this review, we employ the term Treg dysfunction as a comprehensive category that includes quantitative depletion, impaired trafficking, unstable lineage identity, and diminished suppressive function

Though we understand some of the molecular mechanisms that regulate phenotypic switching of VSMCs, and a positive, negative or neutral effect of particular VSMC phenotypes on atherosclerosis and plaque stability, we currently lack experimental evidence in vivo from animal research or correlated data in human studies
This can lead to a better understanding of the pathogenesis of this disease and, consequently, improve treatment tailoring and clinical outcomes

Current knowledge indicates that there are two parallel mechanisms via which tendon repair takes place
Among these, glutathione and vitamin C are often discussed as the heavy hitters
