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The allosteric activator of PrfA is glutathione (GSH) that is produced by the bacterial glutathione synthase GshF

As AWA neurons generate action potentials (Liu et al , 2018), a more realistic model would include the positive feedback loop between the VGCCs, the potassium channels driving the action potential downstroke, and the membrane potential (dictated in part by calcium)

doi: 10.1002/eji.200425822 115 GarrisCSBlahoVAHlaTHanMH

When its extreme, sleep deprivation that goes on for a long time may lead to death
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