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Glutathione turnover is increased during the acute phase of sepsis in rats

This model of metabolic feedback is also observed in antiviral immunity, where lactate suppresses type I interferon production by lactylating the key signaling protein MAVS, revealing an unconventional immunosuppressive function [106]

Free radicals or reactive species through oxidative stress have been evidently implicated in the incidence and progression of several health conditions such as atherosclerosis, diabetes, cancer, neurodegenerative disorders, cardiovascular disorders and other chronic conditions.1 Oxidative stress is a cellular phenomenon or condition which occurs as a result of physiological imbalance between the levels of antioxidants and oxidants (free radicals or reactive species) in favour of oxidants (Fig