Acetaminophen toxicity
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Adv Cancer Res 2014;122:143-75
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
Furthermore, the loss of the tumor suppressor gene p53 is another significant molecular mechanism, as approximately 55% of ovarian cancer cases are associated with a deficiency in this gene [5]
It modulates gene expression, upregulating genes involved in tissue repair while downregulating those associated with inflammation and tissue breakdown
doi: 10.1016/j.bcp.2025.116932 183 ZhuXYangYMaoSLiuQLiYYangYet al
