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By inhibiting NNMT, 5-Amino-1MQ raises intracellular NAD+ and SAM levels, producing downstream effects on fat cell differentiation and metabolic rate

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Clinical trials measuring serum IGF-1 in approximately 900 participants found zero change with AOD-9604 treatment at all doses tested

Effects of NNMT inhibitors on 3T3-L1 cell viability The cytotoxic effects of three membrane-permeable NNMT inhibitors, 5-amino-1MQ, 7-amino-1MQ, and 2,3-diamino-1MQ were evaluated in 3T3-L1 pre-adipocytes