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Indeed, increasing evidence suggests that the gut microbiota plays an integral role in the pathophysiology of hypothyroidism (Samuels and Bernstein, 2022)
Our data indicate a potential acetyl-cystein state only occurring transiently as acetylated wild type SnCE1 is active as deSUMOylase and an accessible Cys256 is essential for catalysis
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Rayment SJ, Shaw J, Woollard KJ, Lunec J, Griffiths HR (2003) Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression
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