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Response: CMS thanks commenters for their thoughtful input

Seek urgent medical attention (via NHS 111 or 999 in an emergency) if you experience severe or persistent abdominal pain, persistent vomiting, signs of dehydration (such as dizziness, reduced urination, or extreme thirst), or symptoms suggestive of low blood sugar (such as shakiness, sweating, or confusion)

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At standard doses of 1 mg or less daily, side effect rates were similar to placebo