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TOX/TOX2 and NR4A13 function as central regulators that cooperate to establish and maintain an exhaustion program through chromatin remodeling and epigenetic stabilization ( Mechanistically, mitochondrial stress provides a plausible bridge between these states

NADPH Oxidase-Derived ROS: Key Modulators of Heme-Induced Mitochondrial Stability in Human Neutrophils

therefore, it was not randomized

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Efficacy and safety of guselkumab therapy in patients with moderately to severely active Crohns disease: results of the Galaxi 2 & 3 phase 3 studies