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"Hepatocyte growth factor as an enhancer of NMDA currents and synaptic plasticity in the hippocampus." Neuroscience

In fact, at endpoint B, decreased SAM levels were observed in MOD group ( P = 0.0010), without, however, any change in SAM/SAH ratio

Medication Interactions Certain medications reduce the absorption of methylcobalamin, cyanocobalamin, and other B12 supplements, including: Proton pump inhibitors (omeprazole, esomeprazole, and lansoprazole) H2-receptor antagonists (cimetidine, famotidine, and ranitidine) Metformin Colchicine Cholestyramine Certain antibiotics (neomycin and chloramphenicol) If you use these or other medications, talk with a healthcare provider about ways to maintain healthy levels of B12.

But that is different from saying there is no signal

Don't promise it's a guaranteed treatment or cure