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Dysfunction of other TRP channels have also been identified, including the increased expression of the sensory ion channel TRPV1 [201] and TRPM2 [202] in ME/CFS

Statistical analyses A descriptive analysis (mean, median and range) of the patients characteristics was performed for phase 1 and phase 2 of the DIVE-1 study

Besides, vitamin B12, methylcobalamin has neurological effect indirectly, methylation of myelin shelth phospholipids via 5-methyltetrahydroxyfolate-homocystine methyltransferase (MTR) reaction

Multivariate statistical analysis was performed using MetaboAnalyst v5.0 (Xia Lab, McGill University, Montreal, Quebec, Canada