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Oral supplementation with phosphatidylcholine (250 mg of total choline from food plus 250 mg of supplemental phosphatidylcholine) has been found to result in detectable concentrations of trimethylamine and trimethylamine N-oxide (TMAO) in the blood (23)

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Whilst inclusion of more chemicals with antagonistic activity would be desirable for mechanistic understanding and complete characterisation of a chemicals activity towards the respective receptor, such information was scarce, and support from human health-relevant studies (i.e., human in vivo information) was lacking