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Description
This investigator's evaluation of a drug that is still undergoing the pre-approval process makes a Phase 4 trial unlikely
There is substantial evidence that Nrf2ARE pathway activators show greater resistance to neurotoxins including MPTP, paraquat and rotenone in both in vivo and in vitro models (Wang et al
The limited human evidence is the elephant in the room
Additionally, betaine can protect mitochondrial function by protecting complex II activity and inhibiting apoptosis by inhibiting caspase-3, thereby maintaining hepatocyte structural integrity (21, 126, 131, 132)
doi: 10.1080/07315724.2001.10719040
