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High-performance liquid chromatography, high-resolution mass spectrometry and tandem mass spectrometry (HPLCMS/MS) for metabolite profiling began to suggest that reduced levels of NAD+ is one of the underlying causes of metabolomic problems

Progression of disease is followed by an increase in redox disbalance.

Manganese superoxide dismutase isoform is dominant in all groups and its relative activities are significantly higher than activities of a copper/zinc isoform

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