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Under steady-state conditions, even during acute lung inflammation, the efficient cellular clearance of alveolar macrophages results in a minimal presence of apoptotic cells in the airways
The higher effective dose from injection translates to more pronounced biological effects
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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) is the master coactivator of mitochondrial biogenesis, serving as an effector molecule in a variety of signaling pathways, such as the mTOR [55], AMPK [56] and MAPK signaling pathways [57], and inhibiting pathways such as the PD-1 signaling pathway
About 50% of patients with bulbar-onset ALS experience depression and extreme emotional states where they laugh or cry for no apparent reason
