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These concentrations were based on previous studies (Bertoncello et al., 2018

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Grape Seed Extract and Rosehip Extract support skin regeneration and reduce oxidative damage to skin cells
Notably, Grx2 is not sensitive to deactivation by electrophilic or oxidative stress

p53 is a transcription factor that regulates the expression of the stress response genes and many anti-proliferative processes, and p53 inhibits cancer cell growth and proliferation by activating p21, a stop signal for cellular division