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The injection of methotrexate caused an increase in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, triacylglycerides, and low-density lipoprotein-cholesterol, and a decrease in high-density lipoprotein-cholesterol (HDL-cholesterol)

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For instance, GPS activates the PI3K/Akt pathway, leading to increased phosphorylation of Akt, which enhances cell survival, proliferation, and migration (Wang X