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Deficiency is widespread in the UK due to limited sunlight exposure, and is particularly prevalent in those with chronic illness, darker skin tones, or conditions affecting fat absorption

The most commonly reported side effects are minor and short-lived

Probiotics, which produce neuroactive compounds, reduce inflammation, and improve gut barrier function, show promise in modulating ENS function

Alteration of the gut microbiota in tumor necrosis factor- antagonist-treated collagen-induced arthritis mice
