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With respect to antifolates, several drugs inhibiting key enzymes in folate metabolisms, e.g., dihydrofolate reductase (DHFR), thymidylate synthase (TS), and glycinamide ribonucleotide formyltransferase (GARTFase) [87], were evaluated for FR-targeting and anti-arthritic activity in vitro or in arthritic animals

Examples include syntheses from S-malic acid [44] or D-mannitol [45]

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Ferroportin-mediated iron export from vascular endothelial cells in retina and brain

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