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Figure 1 shows the anatomical location of the brain areas listed in Table 1 for negative BOLD volume of activation presented as 2D statistical heat maps

First, it inhibits the enzyme tyrosinase, which plays a key role in producing melanin

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LCN2 enhances M2-type macrophage proportions via IL-6 and TNF- (Zheng, 2023), while CCN3 promotes NF-B p65, TGF-1, TGF-R, and p-Smad2/3 expression, increasing IL-6 and TNF- production (Zhu et al., 2020)

[DOI] [PubMed] [Google Scholar] 167.Pammi M., Preidis G.A., Tarnow-Mordi W.O